Search results for "Aortic tissue"

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Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients

2020

microRNAs (miRNAs) are small RNAs that regulate different biological processes. Our objective was to identify miRNAs dysregulated in plasma and tissue of patients with abdominal aortic aneurysm (AAA) and explore new potential targets involved in AAA. Fifty-seven subjects were recruited for a plasma study (30 AAA patients, 16 healthy volunteers and 11 patients with atherosclerosis). The expression level of 179 miRNAs was screened in plasma from a subset of samples, and dysregulated miRNAs were validated in the entire study population. Dysregulated miRNAs were also quantified in aortic tissue of 21 AAA patients and 8 organ donors. Applying a gene set enrichment analysis, an interaction map of…

Male0301 basic medicinePathologymedicine.medical_specialty030204 cardiovascular system & hematologyArticleCatalysisInorganic Chemistrylcsh:Chemistry03 medical and health sciences0302 clinical medicineabdominal aortic aneurysmmicroRNAHealthy volunteersAortic tissuemedicineHumansPhysical and Theoretical ChemistryMolecular BiologyGenelcsh:QH301-705.5SpectroscopyAgedbusiness.industryVascular diseaseGene Expression ProfilingOrganic Chemistrybiomarkersvascular diseaseGeneral MedicineMiddle AgedAtherosclerosismedicine.diseaseAbdominal aortic aneurysmComputer Science ApplicationsmicroRNAs030104 developmental biologylcsh:Biology (General)lcsh:QD1-999Case-Control StudiesmiRNAsPopulation studyFemalebusinessThrombospondin-2Aortic Aneurysm AbdominalInternational Journal of Molecular Sciences
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Hereditariness of Aortic Tissue: In-Vitro Time-Dependent Failure of Human and Porcine Specimens

2018

This study aims to investigate the time dependent failure of aortic tissues for pathological and healthy samples by biomechanical testing. The experimental campaign has involved human pathological tissue and healthy swine tissue as preliminary study towards the development of novel failure criteria.

Pathologymedicine.medical_specialtySettore MED/09 - Medicina Internabusiness.industryRenewable Energy Sustainability and the EnvironmentEnergy Engineering and Power TechnologyComputer Science Applications1707 Computer Vision and Pattern RecognitionBiomechanical testingmedicine.diseaseATAAAneurysmIn vitrocreep failureIndustrial and Manufacturing Engineeringaortic tissue biomechanicAneurysmComputer Networks and CommunicationArtificial IntelligenceAortic tissuehereditarineMedicinebusinessSettore ICAR/08 - Scienza Delle CostruzioniPathologicalInstrumentation
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